Deadly Plant as a Cancer Medicine ?
Deadly Plant as a Cancer Medicine - A beautiful Mediterranean plants are now being developed into new medicines for cancer. Plants that are often called 'death carrot' was being studied by a team of international researchers. The Latin name that sounds beautiful plant is Thapsia garganica. However, the plant was dangerous for sheep and cattle.
The researchers stated the plants can kill cancer cells. It works by blocking the SERCA protein that helps cells control the level of internal calcium.
The challenge in using the plants are harnessing the power of a toxic substance. Toxic was then transformed into a cancer cell killer and leave healthy cells alone.
Samuel Denmeade, an oncologist at Johns Hopkins University in Baltimore, has made a hard task. He and his team spent 15 years of analog engineering thapsigargin, which is the active ingredient plant, to fight cancer cells exclusively. His team modify thapsigargin molecule by adding an extra peptide chains that prevent the toxins enter the cell.
They finally found PSMA (an enzyme found in prostate cancer cell surface). PSMA cut an additional chain of toxins, release him to kill the cells that destroy.
The new poison of this unique plant is not only destroying the cancer cells grow, they also make other cells that could help the growth of cancer cells to 'sleep'.
"You can imagine it as a grenade. One man pulled out one of the pin, but it can kill all the people standing around," said Denmeade.
Sudha research was published in Science Translational Medicine.
The researchers stated the plants can kill cancer cells. It works by blocking the SERCA protein that helps cells control the level of internal calcium.
The challenge in using the plants are harnessing the power of a toxic substance. Toxic was then transformed into a cancer cell killer and leave healthy cells alone.
Samuel Denmeade, an oncologist at Johns Hopkins University in Baltimore, has made a hard task. He and his team spent 15 years of analog engineering thapsigargin, which is the active ingredient plant, to fight cancer cells exclusively. His team modify thapsigargin molecule by adding an extra peptide chains that prevent the toxins enter the cell.
They finally found PSMA (an enzyme found in prostate cancer cell surface). PSMA cut an additional chain of toxins, release him to kill the cells that destroy.
The new poison of this unique plant is not only destroying the cancer cells grow, they also make other cells that could help the growth of cancer cells to 'sleep'.
"You can imagine it as a grenade. One man pulled out one of the pin, but it can kill all the people standing around," said Denmeade.
Sudha research was published in Science Translational Medicine.
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